Overview
Research and Innovation Associate – Strand, London, WC2R 2LS
About us
The postholder will work on a 3-year MRC funded project based in the Liu Lab in the Centre for Craniofacial and Regenerative Biology (CCRB) at King’s College London, in collaboration with the Trizzino lab based at Imperial College London.
The postholder will work closely with Prof Karen Liu and Dr Marco Trizzino and with techs, postdocs and PhD students within the Liu and Trizzino labs. Key desired skills include experience with human and animal models, tissue culture, expression analysis, molecular biology, advanced imaging of cell migration.
Postholder will be responsible for maintaining mouse lines and mouse tissue culture lines and will also have access to human stem cell approaches. Techniques may include genotyping, immunohistochemistry, biochemistry, light and confocal microscopy imaging. Engagement with research aims may lead to co-authorship. Additional training and career development opportunities will be strongly encouraged.
The primary employment site will be at the Guy’s Hospital Campus, London, in the Centre for Craniofacial and Regenerative Biology (CCRB). Work in CCRB focuses on mechanisms that control head development and repair, underpinning a broad understanding of the genetic basis of congenital malformations and disease. Research in CCRB is multidisciplinary using different experimental models and techniques to explore cell signalling, transcriptional networks and cell behaviour during development and disease. The department has over 60 research staff with major funding from the Medical Research Council, Biotechnology and Biomedical Science Research Council, ARC, Wellcome Trust and European Commission. Groups occupy newly refurbished laboratories with core facilities on floor 27 of Guy’s Tower Wing, Guy’s Hospital.
About the role
The postdoc will work on modelling congenital CHD3 anomalies using mouse and human models within the Liu Lab in the Centre for Craniofacial and Regenerative Biology at King’s College London and within the Trizzino lab at Imperial College London. Overall aim of the project is to understand the significance of clinically relevant gene variants in CHD3, which causes Snijders-Blok-Campeau Syndrome, and to test the hypothesis that CHD3 specifically regulates development, migration and specification of the neural crest lineage (Mitchell et al., EMBO Reports, 2025).
The postdoc will work closely with Prof Karen Liu, techs, postdocs and PhD students within the Liu lab, with regular interactions and shared meetings with the Trizzino lab. Key desired skills include embryology, tissue culture, biochemistry, gene editing, molecular biology, advanced imaging and database management.
Postdoc will be responsible for establishing and maintaining cell lines and assessing cellular phenotypes. Techniques may include microdissection, molecular biology, biochemistry, immunohistochemistry, light and confocal microscopy imaging. Engagement with research aims may lead to co-authorship. Additional training and career development opportunities for postdocs will be strongly encouraged.
The primary employment site will be at the Guy’s Hospital Campus, London, in the Centre for Craniofacial and Regenerative Biology (CCRB). Work in CCRB focuses on mechanisms that control head development and repair, underpinning a broad understanding of the genetic basis of congenital malformations and disease. Research in CCRB is multidisciplinary using different experimental models and techniques to explore cell signalling, transcriptional networks and cell behaviour during development and disease. The department has over 60 research staff with major funding from the Medical Research Council, Biotechnology and Biomedical Science Research Council, ARC, Wellcome Trust and European Commission. Groups occupy newly refurbished laboratories with core facilities on floor 27 of Guy’s Tower Wing, Guy’s Hospital.
Informal enquiries welcome to karen.liu@kcl.ac.uk
This is a full time post (35 hours per week), and you will be offered an a fixed term contract until 30/09/2028
Research staff at King’s are entitled to at least 10 days per year (pro-rata) for professional development. This entitlement, from the Concordat to Support the Career Development of Researchers, applies to Postdocs, Research Assistants, Research and Teaching Technicians, Teaching Fellows and AEP equivalent up to and including grade 7. Visit the Centre for Research Staff Development for more information.
