​​The School of Cardiovascular & Metabolic Medicine & Sciences (SCMMS) provides an outstanding multi-disciplinary environment for the pursuit of cutting-edge cardiovascular and metabolic research ( https://www.kcl.ac.uk/scms).  

 

​ ​We study the fundamental molecular, cellular, and physiological processes that underly normal and abnormal cardiovascular and metabolic function and we drive the translation of this strong basic science into advances in clinical practice to improve prevention, diagnosis and treatment.  This activity provides a high-quality research and training environment for non-clinical and clinical scientists.  

​ ​The School occupies facilities across the Guy’s, St Thomas’ and Denmark Hill campuses of King’s College London and comprises over 65 academic groups, hosting 400 staff and 110 PhD students.  

 

​​Our community of world-renowned researchers and educators have access to a state-of-the art core facilities and expertise, including for high-throughput screening, multimodality in vivo imaging, proteomics, integrative physiology and viral & non-viral vector production. As part of King’s Health Partners, we have an excellent environment for basic-clinical interaction and a strong focus on mentoring and career development.  

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​The School is a partner of the NIHR Biomedical Research Centre at Guy’s and St. Thomas’, which offers world class facilities for translational studies and phase I/II clinical trials.​  

 

Dr Rudyk’s lab aims to understand oxidation-based and metabolic mechanisms underlying vascular changes in cardiovascular homeostasis and disease. The successful candidate will broadly investigate how oxidant signalling regulates growth-related kinases in the vasculature; the roles of these processes in maintaining health (vasodilation, pulmonary vascular cell proliferation) and/or their dysregulation during disease, such as pulmonary hypertension. There is flexibility in the precise experimental approach, which will be tailored to the interests, skills and training ambitions of the successful applicant.

 

A variety of methods and skills are suitable for this position and may include those related to molecular biology (cell signalling, DNA and protein analyses, fluorescence imaging, redox biochemistry, proteomics, RNA-Seq), and/or physiology or disease model assessment (e.g., chronic hypoxia, pulmonary hypertension, metabolism, vascular myography, echocardiography, blood pressure telemetry). Experience with disease models, such as heart failure or systemic hypertension or other cardiac stress scenarios, is also welcome.

 

The ideal candidate requires a PhD in a relevant area of research, with a good track record of publishing their work in leading journals, using the methods and skills listed above. You must be ambitious, strongly research-motivated and reliable, with good organisational, verbal and interpersonal skills and attention to detail, willing to work self-driven on your own and as part of a research team. You will also be able to communicate well, both in writing and orally, and to work independently and as part of a team.

 

The post will be based at the School of Cardiovascular and Metabolic Medicine & Sciences, located at St Thomas’ Hospital. The post is funded by the British Heart Foundation and will be offered on a fixed-term contract for 16 months in the first instance.  This is a full-time post – 100% full-time equivalent 35 hours/week.

 

Research staff at King’s are entitled to at least 10 days per year (pro-rata) for professional development. This entitlement, from the  Concordat to Support the Career Development of Researchers, applies to Postdocs, Research Assistants, Research and Teaching Technicians, Teaching Fellows and AEP equivalent up to and including grade 7. Visit the  Centre for Research Staff Development for more information.